|
Symbol Name ID |
Ciita
class II transactivator MGI:108445 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Agammaglobulinemia |
Panhypogammaglobulinemia |
Cutaneous anergy |
Neutropenia |
Leukopenia |
Recurrent upper respiratory tract infections |
Pericarditis |
Lymphadenopathy |
Colitis |
Viral hepatitis |
Cholangitis |
Lupus nephritis |
Nephritis |
Recurrent urinary tract infections |
Abnormality of the immune system |
Chronic mucocutaneous candidiasis |
Discoid lupus rash |
Malar rash |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Anti-citrullinated protein antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Recurrent bacterial infections |
Recurrent fungal infections |
Recurrent protozoan infections |
Recurrent lower respiratory tract infections |
Recurrent viral infections |
Infectious encephalitis |
Chronic lymphocytic meningitis |
| Disease(s) Associated with CIITA | |||||||||||||||||||||||||||||||||||||||
| MHC class II deficiency | |||||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis | |||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
decreased T cell proliferation |
pancreas inflammation |
insulitis |
periinsulitis |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
increased double-positive T cell number |
decreased dendritic cell number |
abnormal T cell subpopulation ratio |
decreased CD4-positive, alpha-beta T cell number |
absent CD4-positive, alpha-beta T cells |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased osteoclast cell number |
abnormal lymphocyte physiology |
abnormal B cell physiology |
abnormal immunoglobulin level |
decreased IgG level |
increased IgM level |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal MHC II cell surface expression on macrophages |
abnormal popliteal lymph node morphology |
abnormal immune system physiology |
abnormal dendritic cell physiology |
abnormal level of surface class II molecules |
impaired humoral immune response |
abnormal cytokine secretion |
decreased susceptibility to autoimmune diabetes |
decreased susceptibility to experimental autoimmune encephalomyelitis |
abnormal inflammatory response |
abnormal susceptibility to infection |
decreased susceptibility to parasitic infection |
increased susceptibility to parasitic infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
| Ciitam1Btlr/Ciitam1Btlr | ||||||||||||||||||||||||||||||||||||||
| Ciitatm1.1Dim/Ciitatm1.1Dim | ||||||||||||||||||||||||||||||||||||||
| Ciitatm1Adm/Ciitatm1Adm | ||||||||||||||||||||||||||||||||||||||
| Ciitatm1Ccum/Ciitatm1Ccum | ||||||||||||||||||||||||||||||||||||||
| Ciitatm1Jpyt/Ciitatm1Jpyt | ||||||||||||||||||||||||||||||||||||||
| Ciitatm1Wrth/Ciitatm1Wrth | * | |||||||||||||||||||||||||||||||||||||
| Ciitatm2Wrth/Ciitatm2Wrth | * | |||||||||||||||||||||||||||||||||||||
| Ciitatm1Adm/Ciita+ | ||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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